| Test Name: |
QUEST AD-DETECT® BETA-AMYLOID 42/40 RATIO, PLASMA |
| Test Code: |
2194411 |
| Alias: |
AB42/40
ABeta 40
ABeta 42
ABeta 42/40
Alzheimer’s Disease (AD)
LAB15501
|
| CPT Code(s): |
0346U
|
| Test Includes: |
ABeta 42
ABeta 40 ABeta 42/40 Ratio |
| Preferred Specimen: |
1.2 mL plasma collected in K2 EDTA tube |
| Container: |
Lavender K2 EDTA tube |
| Minimum Volume: |
0.6 mL plasma |
| Collection Instructions: |
Collect blood into a K2 EDTA Plasma tube and mix by inversion 10 times. Centrifuge to separate plasma from cells within 1 hour of collection. Carefully transfer plasma into a non-conical polypropylene tube or a polypropylene (non-conical) pour-off/ transfer tubes. If unable to centrifuge within 1 hour of collection, store tube on ice. Store frozen. |
| Transport Temperature: |
Frozen |
| Stability: |
Room temperature: Unacceptable
Refrigerated: 72 hours Frozen: 77 days |
| Rejection Criteria: |
Moderate or gross hemolysis • Specimen collected in a glass, polystyrene, or polycarbonate tube |
| Schedule: |
Set up: Sun; Report available: 4-13 days |
| Method: |
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) |
| Performing Lab: |
Quest Diagnostics Wood Dale > SJC; # 11786 |
| Clinical Significance: |
Quest AD-Detect® Beta-Amyloid 42/40 Ratio, Plasma - This LC-MS/MS assay measures beta-amyloid 40 (AB40) as well as AB42 in plasma, rather than AB42 alone. This permits the normalization of beta amyloid levels circulating in plasma in different patients. Using the ratio of beta-amyloid 42/beta-amyloid 40, improves sensitivity and specificity for detecting Alzheimer's disease. |
| Use: |
Updated: 06/25/2024 |
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The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
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| Test Type: |
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