UroSwab

ThinPrep

Firmly, yet gently, obtain sample with the OneSwab, rotating it 360^o for 10-30 seconds to ensure adequate sampling. When sampling a crusted over lesion, moisten the swab in sterile saline prior to taking the sample. Remove the swab and place into the vial. Snap off the shaft to fit completely in the vial. Be sure the swab fits into the vial prior to capping. Tightly cap the vial.

Next Generation Sequencing

Papillomaviruses are a diverse group of viruses that have been found in more than 20 different mammalian species. To date, more than 115 distinct HPV subtypes have been identified. HPV infection is very common, although most infected individuals eliminate evidence of the virus without developing clinical manifestations. Therefore, very few HPV-infected individuals progress to invasive cervical cancer. HPV type is a well established risk factor determinant for progression to cervical cancer. Over 40 HPV types infect the anogenital tract, 15 of them have been classified as high-risk for development of cervical cancer, 3 have been classified as probable high-risk, 12 have been classified as low-risk and 3 are considered undetermined-risk An HPV type is defined as a complete genome whose L1 gene sequence is at least 10% dissimilar to that of any other HPV type. Each Papillomavirus is highly tropic for a specific epithelium, and has its own degree of oncogenicity. HPV Type-Detect® 3.0 targets the L1 major capsid region. This region is a suitable target, because a diverse genetic region is contained within a more conserved region for all the detected HPV subtypes. This assay detects and distinguishes between nineteen different subtypes, both high-risk and low-risk.