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Test Name:	Cardio IQ® Lp-PLA2 Activity
Test Code:	2192577
Alias:	LAB12401
CPT Code(s):	83698
Preferred Specimen:	1 mL serum
Container:	SST
Minimum Volume:	0.5 mL
Collection Instructions:	Patient preparation: Fasting is preferred, but not required. Gently invert tube 5 times immediately after draw. DO NOT SHAKE. Allow specimen to completely clot. Centrifuge for 10 minutes.
Transport Temperature:	Refrigerated
Stability:	Room Temperature: 7 days Refrigerated: 28 days Frozen: 28 days
Rejection Criteria:	Hemolysis • Moderate to grossly lipemic • Moderate to grossly icteric
Limitations:	This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Schedule:	Set up: Mon-Sat; Report available: 3-4 days from receipt at CHL
Method:	Enzymatic Assay (EZA)
Performing Lab:	Quest Diagnostics, Valencia #94218 > CHL
Clinical Significance:	Cardio IQ® Lp-PLA2 Activity - Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet activating factor Acetylhydrolase, is an inflammatory enzyme that circulates bound mainly to low density lipoproteins and has been found to be localized and enriched in atherosclerotic plaques. In multiple clinical trials, Lp-PLA2 activity has been shown to be an independent predictor of coronary heart disease and stroke in the general population. Measurement of Lp-PLA2 may be used along with traditional cardiovascular risk factor measures for identifying individuals at higher risk of cardiovascular disease events. Clinical management may include beginning or intensifying risk reduction strategies. The activity assay is an enzyme assay run on an automated chemistry platform.
Use:	Updated: 5/2/2023
Reference Ranges:	Risk Optimal ≤123 nmol/min/mL High >123 nmol/min/mL

	The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
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