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Test Name:	QUEST AD-DETECT® BETA-AMYLOID 42/40 RATIO, PLASMA
Test Code:	2194411
Alias:	AB42/40 ABeta 40 ABeta 42 ABeta 42/40 Alzheimer’s Disease (AD) LAB15501
CPT Code(s):	0346U
Test Includes:	ABeta 42 ABeta 40 ABeta 42/40 Ratio
Preferred Specimen:	1.2 mL plasma collected in K2 EDTA tube
Container:	Lavender K2 EDTA tube
Minimum Volume:	0.6 mL plasma
Collection Instructions:	Collect blood into a K2 EDTA Plasma tube and mix by inversion 10 times. Centrifuge to separate plasma from cells within 1 hour of collection. Carefully transfer plasma into a non-conical polypropylene tube or a polypropylene (non-conical) pour-off/ transfer tubes. If unable to centrifuge within 1 hour of collection, store tube on ice. Store frozen.
Transport Temperature:	Frozen
Stability:	Room temperature: Unacceptable Refrigerated: 72 hours Frozen: 77 days
Rejection Criteria:	Moderate or gross hemolysis • Specimen collected in a glass, polystyrene, or polycarbonate tube
Schedule:	Set up: Sun; Report available: 4-13 days
Method:	Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Performing Lab:	Quest Diagnostics Wood Dale > SJC; # 11786
Clinical Significance:	Quest AD-Detect® Beta-Amyloid 42/40 Ratio, Plasma - This LC-MS/MS assay measures beta-amyloid 40 (AB40) as well as AB42 in plasma, rather than AB42 alone. This permits the normalization of beta amyloid levels circulating in plasma in different patients. Using the ratio of beta-amyloid 42/beta-amyloid 40, improves sensitivity and specificity for detecting Alzheimer's disease.
Use:	Updated: 06/25/2024

	The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
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