Test Name: CARDIOLIPIN IgG ANTIBODY
Test Code: 2320111
Alias: ACA IgG
Antiphospholipids IgG
Immunoglobulin G
LAB3012
CPT Code(s): 86147  
Preferred Specimen: 1.0 mL serum
Container: SST (gold)
Minimum Volume: 0.5 mL serum
Transport Temperature: Refrigerated
Stability:

Refrigerated: 7 days

 
Rejection Criteria: Hemolysis
Limitations:

Anti-cardiolipin antibodies also occur transiently in a variety of infectious diseases.  In these cases, patients positive for anti-cardiolipin antibodies should be retested following an appropriate interval.  Confirmed active or seropositive syphilis patients can have elevated cardiolipin antibody levels.

The anti-cardiolipin test can produce false positive results due to cross-reactivity with dsDNA antibodies.

Schedule:

Set-up: Monday and Thursday; Results in 1-5 days
Method:

Multiplex bead immunoassay

Clinical Significance: Anti-cardiolipin antibodies (ACA) have been strongly associated with venous and arterial thrombosis.  These findings were first observed during studies on Systemic Lupus Erythematosus (SLE), a disease whose many symptoms include thrombosis.  Of the many autoantibodies found in SLE, two were found to be directed against phospholipids such as cardiolipin.
Use:

Updated: 8/4/25
Reference Ranges:

Cardiolipin IgG:
             Negative              <20 GPL  
             Positive                >=20 GPL
             

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The CPT codes included in this publication are in accordance with Current Procedural Terminology, a publication of the American Medical Association. CPT codes are provided here for the convenience of our clients; however, correct coding often varies from one carrier to another, and HealthLab may bill specific carriers using codes other than those shown. Clients who bill for services should verify the code(s) with the applicable payor to confirm that their use is appropriate in each case.
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