Test Name: ANTI-ENA6 PLUS DFS70 AB PROFILE
Test Code: 2194661
Alias: 520301
LAB15779
CPT Code(s): 83516   86235 x 6  
Test Includes: Anti-DFS70; Anti-Sm; Anti-U1 RNP; Anti-Ro (SS-A); Anti-La (SS-B); Anti-Scl-70; Anti-Jo-1
Preferred Specimen: 3 mL serum
Container: SST x 2
Alternate Container: Red Top x 2
Minimum Volume: 1.5 mL serum
Collection Instructions: Allow specimen to completely clot. Centrifuge for 15 minutes when specimen is clotted or within 2 hours of collection.
Transport Temperature: Refrigerated
Stability:

Room temperature: 7 days

Refrigerated: 14 days

Frozen: 60 days
Rejection Criteria: Grossly hemolyzed; bacterial contamination; lipemic, icteric, non-serum specimen types
Limitations: This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Additional Information: Anti-ENA6 Plus DFS70Ab Profile
Schedule: Report Available: 14-21 days
Performing Lab: LabCorp #520301
Clinical Significance:

Anti-ENA6 Plus DFS70 is designed to facilitate the proper triage of patients with positive Anti-Nuclear Antibodies (ANA) by identifying those most likely to benefit from a rheumatology specialist. It detects the novel Anti-DFS70 along with 6 other clinically useful autoantibodies to ENA, which may help identify systemic lupus erythematous (SLE), mixed connective tissue disease (MCTD), Sjogren's, systemic sclerosis, and idiopathic inflammatory myopathy (IIM). Positive Anti-DFS70 antibodies in isolation may help identify individuals who do not have an AARD (ANA-associated rheumatic disease), especially in the absence of significant clinical findings.

 

Anti-DFS70 Abs confer a likelihood ratio for the absence of systemic autoimmune rheumatic disease of 10.9 and are detectable in 2% to 22% of healthy individuals and in less than 1% of patients with AARD.
Use: Updated: 04/29/2025

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